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Selpercatinib Significantly Improves PFS Over MKIs in RET-Mutant Medullary Thyroid Cancer

Selpercatinib demonstrated a statistically significant improvement in progression-free survival vs physician’s choice of cabozantinib or vandetanib in patients with advanced or metastatic RET-mutant medullary thyroid cancer, meeting the primary end point of the phase 3 LIBRETTO-531 trial.

Selpercatinib prolongs PFS in RET fusion-positive NSCLC

Selpercatinib prolongs PFS in RET fusion-positive NSCLC
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Phase 3 Study of Selpercatinib Meets Primary PFS End Point in NSCLC

Patients with RET fusion-positive advanced or metastatic non–small cell lung cancer had a survival benefit when treated with selpercatinib in the LIBRETTO-431 study.

Selpercatinib Meets PFS End Point in Newly Diagnosed Advanced or Metastatic RET+ NSCLC

Selpercatinib significantly improved progression-free survival vs platinum-based chemotherapy plus pemetrexed and pembrolizumab in patients with advanced or metastatic non–small cell lung cancer harboring RET fusions.

Selpercatinib by Loxo Oncology for Salivary Gland Cancer: Likelihood of Approval

Selpercatinibis under clinical development by Loxo Oncology and currently in Phase II for Salivary Gland Cancer.

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