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Genomics, Related Research Can Serve as Platforms to Solve Nigeria s Challenges
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Landmark University hosts bioinformatics conference
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(Graphic) K. Franklin/Science
Those databases will illuminate studies of human variation worldwide, in part because the great genomic diversity in Africans can uncover spurious links to medical conditions, explains Concepcion Nierras, an NIH Common Fund geneticist. For example, in Europeans a rare variant of a gene for a low-density lipoprotein that contributes to high cholesterol seemed to raise the risk of heart disease. But Fatumo and his colleagues found that among Africans, the variant was common even in those who did not have heart disease, suggesting it may not have clinical relevance. The
Nature paper uncovered 54 such variants that now need re-evaluation.
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Summary
In 1987, 10-year-old Segun Fatumo was on the streets of Lagos, Nigeria, hawking palm oil, yams, and pepper each day after school to help put food on his family s table. Now, he s a computational geneticist in Uganda and one of dozens of Africans doing a substantial and growing share of genomics research on that continent. Bolstered by the internationally funded Human Heredity & Health in Africa Initiative, these researchers hope to one day use their data to bring genetically tailored medicine to people who in some places still struggle to get electricity and basic health care. The work is beginning to close a wide gap in who benefits from the human genome revolution. Including African populations is also paving the way for a better understanding of the links between disease and genes in everyone, everywhere, because Africa holds more genomic diversity than any other continent. But genomic research in Africa has a long way to go and funding remains