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7 January 2021 Lamotrigine (Lamictal) and levetiracetam (Keppra) have been found to be safer than other antiepileptic drugs in pregnancy. The MHRA advises patients not to stop taking their current medicines without first discussing it with a healthcare professional. The review by the Medicines and Healthcare products Regulatory Agency examined safety data for risks of major birth defects or abnormalities and concerns with the child’s development including learning and thinking abilities for other key antiepileptic drugs. It found that a number of these epilepsy medicines may be associated with some increased risks in pregnancy. Valproate (Epilim) is already known to be seriously harmful if taken in pregnancy and should only be prescribed to a woman if a pregnancy prevention plan is in place. Importantly, two antiepileptic medicines in particular, lamotrigine (Lamictal) and levetiracetam (Keppra), have both been found to be safer than other antiepileptic drugs in pregnancy. The M

United kingdomPaul chrispLamotrigine lamictalJo mountfieldDr sarah branchNational institute for biological standardsRisk management of medicines divisionRoyal college of obstetriciansRegulatory agencyClinical practice research datalinkDepartment of healthCommission on human medicinesCentre for guidelinesAffairs at epilepsy actionSarah branchRisk management