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Scientists reveal the biological process leading to dangerous inflammatory disease in preemies
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Researchers Define Chain of Events Leading to Dangerous Intestinal Disorder in Preemies
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IMAGE: Photomicrographs of tissue taken from the intestines of infant mice and grown in culture as intestinal organoids, or enteroids, that are basically mini-intestines for research. The enteroids shown are from. view more
Credit: C. Sodhi, W. Fulton and D. Hackam, Johns Hopkins Medicine
Medical researchers have long understood that a pregnant mother s diet has a profound impact on her developing fetus s immune system and that babies especially those born prematurely who are fed breast milk have a more robust ability to fight disease, suggesting that even after childbirth, a mother s diet matters. However, the biological mechanisms underlying these connections have remained unclear.
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IMAGE: Photomicrographs demonstrating the impact of T lymphocytes (T cells) associated with the intestinal disease necrotizing enterocolitis (NEC) on myelin a fatty material that surrounds and protects nerve cells . view more
Credit: C. Zhou, C. Sodhi and D. J. Hackam, Johns Hopkins Medicine
Physicians have long known that necrotizing enterocolitis (NEC), a potentially lethal inflammatory condition that destroys a premature infant s intestinal lining, is often connected to the development of severe brain injury in those infants who survive. However, the means by which the diseased intestine communicates its devastation to the newborn brain has remained largely unknown.