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Optogenetic Study Identifies Therapeutic Target for Inflammatory Diseases and Neuropathic Pain

Combining optogenetics, cre recombination mediated neuron-specific mutations, sciatic nerve-injury, and disease models of arthritis, with direct measurements of inflammation and neuropathic pain, scientists at the Feinstein Institutes show that the release of the nociceptor protein HMGB1 is required to mediate neuropathic pain (allodynia) and inflammation. The preclinical study provides direct evidence that nociceptor-related pain can be prevented by targeting HMGB1 in new therapeutic approaches to treat neuroinflammatory diseases.

Feinstein Institutes Bioelectronic Medicine Researchers Control Nerve to Turn On/Off Inflammation

Feinstein Institutes Bioelectronic Medicine Researchers Control Nerve to Turn On/Off Inflammation
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