"Alas! must it ever be so?
Do we stand in our own light, wherever we go,
And fight our own shadows forever?" -Edward Bulwer-Lytton
Ever since it was conjectured that the speed of light was the ultimate speed limit of the Universe, we have tried with the most powerful of our tools to push as close to it as possible.
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"In any case, the number three fitted perfectly the way quarks occur in nature." -Murray Gell-Mann
You might think that we know it all, at least as far as knowing-it-all is possible. After all, we know that matter is made up of atoms, which are made up of electrons and nuclei, and the nuclei are made up of protons and neutrons, and then the protons and neutrons are made up of quarks and gluons.