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Mitochondrial DNA Dysfunction Points to Potential Therapeutic Targets against Inflammation

Mitochondrial DNA Dysfunction Points to Potential Therapeutic Targets against Inflammation
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Faulty DNA disposal system found to cause inflammation

Faulty DNA disposal system found to cause inflammation
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Faulty DNA disposal system causes inflammatio

<p>Salk scientists discovered a pathway from mitochondrial DNA replication stress to immune system activation and inflammation, finding that endosomes responsible for disposing of dysfunctional mitochondrial DNA were leaking&nbsp;mitochondrial DNA into the cell and prompting the inflammatory immune response. The pathway provides new targets for therapeutics that disrupt inflammation during aging and disease.</p>

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