Dimitri Payet scored the equaliser in the 53rd minute and three minutes later, Pol Lirola fired the hosts ahead.
A few minutes later, Moffi linked up with Wissa again to grab his second goal of the day in the 70th minute and the effort was set to rescue a crucial away point for Lorient until Lirola scored a stoppage-time winner for Marseille.
Moffi who moved to France from Belgian club Kortrijk last September, has now scored 11 goals after 27 matches in his debut Ligue 1 season.
The Nigeria star is Lorient s leading top scorer so far but Christophe Pelissier s side is 17th in the Ligue 1 table with 32 points from 33 matches - two points adrift of the relegation zone.
Moffi s double not enough as Marseille edge Lorient in five-goal thriller
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Revivez Lyon-Bordeaux (2 - 1)
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