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Winding Back the Clock: What If the STAR*D Investigators Had Told the Truth?

The STAR D Study has been cited as real-world evidence of the efficacy of antidepressants. In truth, it told of a failed paradigm of care.

District of columbiaUnited statesColumbia universityNew yorkNew yorkerWilliam coryellNathan klineVan scheyenEd pigottEli lillyGerard sanacoraMichael posternakJd van scheyenLisa cosgroveDonald kleinGunnar lundquist

Our RCT fetish has led to a societal delusion about the merits of antidepressants

While RCTs show that antidepressants provide a statistically significant benefit, there is a large pool of evidence that tells of harm done

District of columbiaUnited statesNew yorkUnited kingdomSamuel guzeJonathan coleEmil kraepelinPaul leberJason aronsomLasse mattilaEli lillyRichard kapitKristoffer magnussonEli lilly dorothy dobbsDavid grahamJoanna moncrieff

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