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Virus-like particles reveal unexpected mechanism for increased fitness and spread of SARS-CoV-2
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New phylogenomic platform identifies increased recombination rates in SARS-CoV-2
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Vaccination may protect against SARS-CoV-2 infection at the eye surface
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“Sybodies” protect against SARS-CoV-2 in hamster model
Researchers in China, The Netherlands, France, and Switzerland have identified synthetic nanobodies or “sybodies” that exhibit potent neutralizing activity against severe acute respiratory syndrome coronavirus (SARS-CoV-2) – the agent responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic.
Structural and biophysical studies revealed that the sybodies stopped the receptor-binding domain (RBD) of the viral spike protein interacting with the human host cell receptor angiotensin-converting enzyme 2 (ACE2).
As recently reported in the journal
Nature Communications, the sybody MR3 exhibited the highest binding affinity for the spike RBD and the most potent neutralizing activity against SARS-CoV-2 pseudoviruses.