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Two monoclonal antibodies broadly neutralize SARS-CoV-2 variants of concern

Researchers in the United States and Canada have described the structural basis and mode of action for two monoclonal antibodies that potently neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

Sybodies protect against SARS-CoV-2 in hamster model

“Sybodies” protect against SARS-CoV-2 in hamster model Researchers in China, The Netherlands, France, and Switzerland have identified synthetic nanobodies or “sybodies” that exhibit potent neutralizing activity against severe acute respiratory syndrome coronavirus (SARS-CoV-2) – the agent responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. Structural and biophysical studies revealed that the sybodies stopped the receptor-binding domain (RBD) of the viral spike protein interacting with the human host cell receptor angiotensin-converting enzyme 2 (ACE2). As recently reported in the journal Nature Communications, the sybody MR3 exhibited the highest binding affinity for the spike RBD and the most potent neutralizing activity against SARS-CoV-2 pseudoviruses.

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