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Bottlebrush Nanoparticles Deliver Immunostimulatory Drugs |

Researchers at MIT have developed a nanoparticle system that is designed to deliver immunostimulatory drugs to tumors. These drugs are intended to

Sachin bhagchandaniScience advances

Study Shows Nanoparticles Encourage Immune Response Against Tumors

Cancer drugs that stimulate the body’s immune system to attack tumors are a promising way to treat many types of cancer. However, some of these drugs produce too much systemic inflammation when delivered intravenously, making them harmful to use in p

Christopher brownJeremiah johnsonTimothy fessendenStefani sprangerRobert langerDarrell irvineAlex shalekMichelle ramseierSachin bhagchandaniGavin kielFarrukh vohidovKoch institute frontier research programNational cancer instituteKathy marble cancer research fundLudwig centerKoch institute for integrative cancer research

Nanoparticles provoke immune response against tumors but avoid side effects: In a new study, immunostimulatory drugs slowed tumor growth without producing systemic inflammation

Nanoparticles provoke immune response against tumors but avoid side effects: In a new study, immunostimulatory drugs slowed tumor growth without producing systemic inflammation
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Sachin bhagchandaniDarrell irvineJeremiah johnsonRagon instituteKoch institute for integrative cancer researchUnderwood prescott professorBiological engineeringMaterials scienceIntegrative cancer research

Nanoparticles Trigger Immune Response Against Tumors, Spare Side Effects

Nanoparticles Trigger Immune Response Against Tumors, Spare Side Effects
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Darrell irvineAlex shalekFarrukh vohidovRobert langerMichelle ramseierJeremiah johnsonTimothy fessendenGavin kielChristopher brownStefani sprangerSachin bhagchandaniKoch instituteNational cancer instituteKoch institute for integrative cancer researchRagon instituteKathy marble cancer research fund

Nanoparticles provoke immune response against tumors but avoid side effects

MIT researchers find that when immunostimulatory drugs called imidazoquinolines are delivered using specialized bottlebrush nanoparticles, the drugs provoke the immune system to attack tumors while eliminating the side effects that occur when the drugs are given on their own.

Alex shalekTimothy fessendenStefani sprangerSachin bhagchandaniDarrell irvineChristopher brownFarrukh vohidovJeremiah johnsonMichelle ramseierGavin kielRobert langerKoch instituteKoch institute for integrative cancer researchKathy marble cancer research fundMarble centerNational cancer institute