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Stem cell therapy promotes recovery from stroke and dementia in mice

UCLA Broad Stem Cell Research Center/Science Translational Medicine Microscope images showing brain tissue that has been damaged by white matter stroke (left) and then repaired by the new glial cell therapy (right). Tiare Dunlap | April 21, 2021 A one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia, a new UCLA study finds. Dementia can arise from multiple conditions, and it is characterized by an array of symptoms including problems with memory, attention, communication and physical coordination. The two most common causes of dementia are Alzheimer’s disease and white matter strokes small strokes that accumulate in the connecting areas of the brain.

Thomas Carmichael elected to the Association of American Physicians

April 9, 2021 Dr. S. Thomas Carmichael has been elected to the Association of American Physicians, an honor society recognizing exemplary physician-scientists who contribute to clinical medicine through the pursuit of basic science. The newly elected members for 2021 were recognized at the association’s annual meeting, which was held virtually April 8–10. In his research, Carmichael studies how the brain rebuilds after a stroke or other injury. “For me, the approach has been bidirectional,” he said. Advances made in the lab translate to new clinical trials, while interactions with patients point to new research directions, Carmichael said. For example, Carmichael recalls seeing several patients with a type of brain disease called vascular dementia, in which a series of small strokes damage the brain. These patients lose their ability to store and retrieve information. It’s devastating, and there’s no cure, he said.

UCLA partners with Yuyu Pharma to study stroke recovery

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