Tatiana Kozyrenko got the hosts off to a bright start after she gave them the lead off Nadezhda Smirnova s assist on the half-hour mark.
After the break, CSKA held on to their narrow lead, although they eventually consolidated their dominance as Onguene doubled their lead when she scored in the 78th minute of the encounter.
As if it was not enough, the champions were awarded a penalty and Nadezhda Smirnova finally got on the scoresheet when she converted from the spot two minutes from full-time.
With her latest goal, Onguene, who was in action from the start to the finish for CSKA, has now increased her tally to four in four and a goal in three consecutive games this season.
Onguene hits brace as CSKA Moscow run riot over Rubin Kazan goal.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from goal.com Daily Mail and Mail on Sunday newspapers.