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Credit: FEFU press office Scientists from Far Eastern Federal University (FEFU) together with Russian and German colleagues, continue studying antitumor compounds synthesized based on bioactive molecules isolated from a sea sponge. One of them fights cancer cells resistant to standard chemotherapy, and at the same time has an interesting dual mechanism of action. A related article appears in Marine Drugs. Scientists have tested the biological effect of the marine alkaloid 3,10-dibromofascaplysin on various prostate cancer cells, including those resistant to standard docetaxel-based chemotherapy. The compound was first isolated from the sea sponge Fascaplysinopsis reticulata and subsequently chemically synthesized in FEFU. The substance forces tumor cells to die via a programmed cell death mechanism. This process is called apoptosis and is considered the most favorable mode of action of anticancer drugs.

Nordrhein westfalenSergey dyshlovoyMaxim zhidkovEastern federal universityRussian foundation for basic researchAv zhirmunsky national scientific centerUniversity medical center hamburgVa engelhardt institute of molecular biologyHead of department organic chemistrySchool of natural sciencesNational scientific centre of marine biology vladivostokFar eastern federal universityNatural sciencesNational scientific centreMarine biologyRussian foundation