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IMAGE: Research from UVA s Jogender Tushir-Singh, PhD, explains why the antibody approaches effectively killed cancer tumors in lab tests but proved ineffective in people. view more
Credit: Dan Addison | UVA Communications
New research from UVA Cancer Center could rescue once-promising immunotherapies for treating solid cancer tumors, such as ovarian, colon and triple-negative breast cancer, that ultimately failed in human clinical trials.
The research from Jogender Tushir-Singh, PhD, explains why the antibody approaches effectively killed cancer tumors in lab tests but proved ineffective in people. He found that the approaches had an unintended effect on the human immune system that potentially disabled the immune response they sought to enhance.
Researchers say theyâve made a discovery in a cancer treatment originally thought not to work Cancer Center (FILE) By Daniel Grimes | April 6, 2021 at 2:22 PM EDT - Updated April 6 at 2:22 PM
CHARLOTTESVILLE, Va. (WVIR) - Researchers at the University of Virginia Cancer Center say theyâve made a discovery that could revive a cancer treatment originally thought not to work.
It is an antibody treatment for solid cancer tumors like ovarian, colon, and triple negative breast cancers. Originally the treatment had an unintended effect, suppressing a personâs immune system in clinical trials.
Now researchers say theyâve figured out a way to make it work.