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25 Apr 2021
In amyotrophic lateral sclerosis and frontotemporal dementia, loss of the RNA-binding protein TDP-43 from the nucleus creates a surge of mis-spliced mRNAs in neurons. So far, only one of these errant transcripts, stathmin-2, has been tied to disease pathology. Now, two preprints uploaded to bioRXiv on April 4 detail another UNC13A. Variants in this gene increase risk for ALS/FTD.
Neurons lacking nuclear TDP-43 mis-splice UNC13A, make less of the protein.
UNC13A risk variants incorporate cryptic exons.
This only occurs in brain and spinal cord tissue harboring TDP-43 deposits.
One paper was penned by researchers led by Pietro Fratta, University College London, and Michael Ward, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland. The second is from the labs of Aaron Gitler, Stanford University, California, and Leonard Petrucelli, Mayo Clinic, Jacksonville, Florida. Both papers report that if TDP-43 binding to UNC13A falters, the transcript is m
ousted president hosni mubarak had bogged the passage of iranian through the see wez canal since egypt severed diplomatic ties with iran after the islamic revolution there in 1979. the israeli government is keeping a particularly close eye on developments in egypt s diplomatic policy now that mubarak has been removed. the kings of bahrain and saudi arabia have met amid fears that bahrain s unrest could spread to its neighbor. saudi king king abdullah invited the king to discuss the enrest wednesday night. the meeting came as anti-government demonstrations in bahrain grow. on tuesday, tens of thousands of shia muslims protested against sunni rule on the streets of the capital manama. sunny muslims also hold power in saudi arabia, despite growing minority shia muslims frustrations in the oil rich east. the country has seen calls on the internet for large scale anti-government demonstration on march 11th. the saudi government on wednesday unveiled a package worth $36 billion