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IMAGE: The vaccine is injected into the subject at the same time as they receive an antimalarial drug. view more
Credit: Universität Tübingen / Paul Mehnert
Sanaria® PfSPZ-CVac is a live vaccine consisting of infectious Plasmodium falciparum (Pf) malaria parasites that are injected into the subject at the same time as they receive an antimalarial drug. The parasites quickly enter the liver where they develop and multiply for 6 days, and then emerge into the blood As soon as the parasites leave the liver, the drug kills them immediately. Thus, the immune system of the vaccinated subject is primed against many parasite proteins and becomes highly effective at killing malaria parasites in the liver to block infection and prevent disease.