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Higher inflammation prior to chemotherapy can predict frailty after chemotherapy ends, the researchers report.
Characterized by weakness, fatigue, weight loss, and slow walking speed, frailty is associated with cancer and its treatments. Scientists are studying the factors that lead to frailty and how to prevent it because it can impact quality of life and how a person of any age endures disease.
“Our findings confirm that oncologists should consider inflammation and frailty in their patients, and perhaps personalize treatment, especially in older adults, to avoid undue risks of chemotherapy toxicity,” says first author Nikesha Gilmore, research assistant professor of surgery at the University of Rochester Medical Center, who conducts studies for Wilmot’s Cancer Prevention and Control program.