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In a new study published in Nature Chemical Biology, an international team of researchers from the University of Georgia, USA, and the Max Planck Institute for Chemical Ecology in Jena, Germany, presents a promising strategy for elucidating metabolic pathways for plant compounds of medicinal importance. The research team studied the biosynthesis of two alkaloids from the plant Catharanthus roseus that are used in human medicine as anti-cancer agents. The genes for the formation of these active substances are expressed in different cell types. By using single-cell analyses, the scientists were able to discover new genes important for biosynthesis and show that the intermediates of the metabolic pathway accumulate in specific cell types. The researchers predict that this methodological approach will provide important new insights into the biosynthesis of many other natural products from the plant kingdom. (Nature Chemical Biology, May 15, 2023, doi: 10.1038/s41589-023-01327-0).

United statesUniversity of georgiaLorenzo caputiSarah oconnorChenxin liRobin buellMethod of researchDepartment of natural product biosynthesisDepartment of natural product biosynthesis in jenaAlkaloid biosynthesis project groupUniversity of georgia centerProfessor at georgia universityApplied genetic technologiesNatural product biosynthesisSaraho connorNatural product