Researchers at Albert Einstein College of Medicine and the City University of New York Graduate School of Public Health and Health Policy have been awarded a five-year, $14.5 million grant from the National Institutes of Health to continue leading and expand their research on HIV treatment and care in five Central African nations.
Researchers at Albert Einstein College of Medicine have designed an experimental drug that reversed key symptoms of Alzheimer’s disease in mice. The drug works by reinvigorating a cellular cleaning mechanism chaperone-mediated autophagy (CMA) that gets rid of unwanted proteins by digesting and recycling them. “Discoveries in mice don’t always translate to humans, especially in Alzheimer’s disease,” said co-study leader Ana Maria Cuervo, MD, PhD, the Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases, professor of developmental and molecular biology, and co-director of the Institute for Aging Research at Einstein. “But we were encouraged to find in our study that the drop-off in cellular cleaning that contributes to Alzheimer’s in mice also occurs in people with the disease, suggesting that our drug may also work in humans.”
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Credit: Albert Einstein College of Medicine
April 22, 2021 (BRONX, NY) Researchers at Albert Einstein College of Medicine have designed an experimental drug that reversed key symptoms of Alzheimer s disease in mice. The drug works by reinvigorating a cellular cleaning mechanism that gets rid of unwanted proteins by digesting and recycling them. The study was published online today in the journal
Cell. Discoveries in mice don t always translate to humans, especially in Alzheimer s disease, said co-study leader Ana Maria Cuervo, M.D., Ph.D., the Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases, professor of developmental and molecular biology, and co-director of the Institute for Aging Research at Einstein. But we were encouraged to find in our study that the drop-off in cellular cleaning that contributes to Alzheimer s in mice also occurs in people with the disease, suggesting that our drug may also work in humans. In the 1990s, Dr. Cuervo discovered
Research shows that a new experimental drug not only slows but also seems to reverse effects of Alzheimer’s disease.
A doctor points to PET scan results that are part of a study on Alzheimer’s disease. (AP Photo/Evan Vucci, File)
(CN) Researchers have designed an experimental drug that appears to reverse key symptoms in the progression of Alzheimer’s disease, even in advanced cases, by cleaning a patient’s system of proteins that appear to contribute to the disease on a cellular level, according to a new study.
Researchers at Albert Einstein College of Medicine in New York used the drug and its cleaning capabilities to reverse and restore various symptoms of the disease in mice, for instance short-term memory loss and impaired walking.