Telitacicept is a recombinant fusion protein that aims to target and neutralize B lymphocyte stimulator and a proliferation-inducing ligand (APRIL), both of which are linked to autoimmunity.
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In about 5% of patients with seropositive RA, C-reactive protein levels were normal despite disease flares during a 5-year period. The findings represent an "underappreciated, persistent phenotype."