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Efficacy and Safety of Tofacitinib in Patients with Polymyalgia Rheumatica (EAST PMR): An open-label randomized controlled trial

Xinlei Ma and co-workers investigate tofacitinib as a possible treatment for patients with polymyalgia rheumatica.

Eteläuomen läiChina national centerNational key researchZhejiang university school of medicineNational genomics data center nucleic acids resChinese academy of sciencesBioinformation beijing institute of genomicsDevelopment program of chinaLibrary prep kit for illuminaEthical committee of the first affiliated hospitalNatural science foundation of chinaFirst affiliated hospitalZhejiang university schoolPolymyalgia rheumaticaCreative commons attribution licenseGenome sequence archive

Review Identifies Criteria Used to Define Anti–TNF-α Failure in Patients With Psoriasis

It’s estimated around 20% of patients will discontinue their first course of anti–tumor necrosis factor-α (anti–TNF-α) and rates increase over time

Psoriasis areaSeverity indexConsolidated standardsReporting trialsGlobal assessmentAnti tnf αModerate to severe psoriasisAnti tumor necrosis factor α

Effect of Repeated Low-level Red Light on Myopia Prevention Among Children in China With Premyopia: A Randomized Clinical Trial | Ophthalmology | JAMA Network Open

This randomized clinical trial assesses the efficacy and safety of a repeated low-level red-light intervention in preventing incident myopia among children in C

Eteläuomen läiXun xuIolmaster carl zeiss meditecXieyi weishikangEyerising ltdNational key rd program of chinaTreatment centerInternational myopia instituteTechnology commissionOutstanding academic technical leaders programEyerising international pty ltdSuzhou xuanjia optoelectronics technologyHospital ethics committeeDepartment of clinical researchChina national medical products administrationInstitute inc

Outcomes After Elective Inguinal Hernia Repair Performed by Associate Clinicians vs Medical Doctors in Sierra Leone: A Randomized Clinical Trial | Global Health | JAMA Network Open

This randomized clinical trial examined outcomes of inguinal hernia surgery performed by associate clinicians vs nonspecialist medical doctors among men in Sier

Sierra leoneUnited statesKarolinska institutetScientific review committeeKarolinska university hospitalAmerican society of anesthesiologistsWorld health assemblyUnited nations population fundSurgical training programmeHuman development indexSierra leone ministry of healthSwedish international development cooperation agencyAmerican college of surgeonsSwedish research councilDepartment of molecular medicineWorld health

Breaking Blind: Antipsychotic Drug Efficacy May Be Overestimated

Only 4 of 188 antipsychotic trials assessed blinding, and in all 4 cases, the blind was broken, potentially leading to an overestimation of the drug effect.

Stefan leuchtMental healthAran tajikaKyoto university graduate schoolReporting trials

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