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Effect of COVID-19 Antiviral Remdesivir Multiplied 10-Fold by Hepatitis C Drugs Effect of COVID-19 Antiviral Remdesivir Multiplied 10-Fold by Hepatitis C Drugs Drugs used to treat hepatitis C render remdesivir 10 times better at inhibiting the coronavirus in cell cultures. [Jenna Luecke/University of Texas at Austin] April 27, 2021 Share Remdesivir, the only antiviral drug approved in the United States for treating COVID-19 patients, is up to 10 times more effective when it is mixed with a repurposed hepatitis C drug. The effect has been observed with several hepatitis C drugs namely, simeprevir, grazoprevir, paritaprevir, and vaniprevir. All four appear to have the same remdesivir-boosting mechanism: inhibition of the SARS-CoV-2 papain-like protease (PL

United statesArthurm fishbergRobertm krugAdolfo garcGaetanot montelionePathogens institute at icahn mount sinaiIcahn school of medicine at mount sinaiGlobal healthRensselaer polytechnic instituteUniversity of texasRensselaer centerIcahn schoolMount sinaiLike protease synergizeSuppress viral replicationCell reports