Researchers from the University of Kentucky’s Sanders-Brown Center on Aging say a paper recently published in Acta Neuropathologica is the most definitive assessment yet of the prevalence of a form of dementia classified in 2019 and now known as LATE. The results show that the prevalence of brain changes from LATE may be roughly 40% in older adults and as high as 50% in people with Alzheimer’s disease.
Now a couple of years after this discovery, Pete Nelson, the R.C. Durr Foundation Chair in Alzheimer s Disease at the University of Kentucky, is working towards
The motivation driving the work of Pete Nelson, M.D., Ph.D., is personal. His grandmother, Sylvia Becker, died with Alzheimer's disease, and he says his mother then grew terrified of developing the disease.
In 2019, a group of international researchers, co-chaired by Pete Nelson, M.D., Ph.D., discovered a new form of dementia named limbic-predominant age-related TDP-43 encephalopathy, more commonly known as LATE. Symptoms of LATE mimic Alzheimer’s disease by causing memory loss and problems with thinking and reasoning in old age. But researchers found the LATE-affected brain looks very different from the Alzheimer's brain. Now a couple of years after this discovery, the world’s first clinical trial for LATE is officially underway by Nelson's colleagues at the University of Kentucky
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