A new study by UT Southwestern's Simmons Cancer Center scientists suggests that lactate, a metabolic byproduct produced by cells during strenuous exercise, can rejuvenate immune cells that fight cancer.
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IMAGE: A UT Southwestern study discovered the molecular mechanism by which tumors defective in DNA mismatch repair respond to immunotherapy. This illustration depicts how cells use a programmed mismatch repair deficiency-activated. view more
Credit: Illustration by Yipin Wu
DALLAS - Dec. 17, 2020 - DNA that ends up where it doesn t belong in cancer cells can unleash an immune response that makes tumors more susceptible to immunotherapy, the results of two UT Southwestern studies indicate. The findings, published online today in
Cancer Cell, suggest that delivering radiation - which triggers DNA release from cells - before immunotherapy could be an effective way to fight cancers that are challenging to treat.