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 E-Mail BOSTON - New research led by a team at Massachusetts General Hospital (MGH) points to a promising strategy to boost tumors intake of cancer drugs, thereby increasing the effectiveness of chemotherapy treatments. The group s findings are published in Getting enough anticancer drugs into a tumor is often difficult, and a potential strategy to overcome this challenge involves binding the medications to albumin, the most abundant protein in blood. The strategy relies on tumors large appetite for protein nutrients that fuel malignant growth. When consuming available albumin, the tumors will inadvertently take in the attached drugs. A popular albumin-bound drug approved by the U.S. Food and Drug Administration is nanoparticle albumin-bound paclitaxel (nab-PTX), and it has been successfully used to treat late-stage lung and pancreatic cancers. Not all patients respond to nab-PTX, though, and the effectiveness of its delivery to tumors has been mixed, owing to an incomplete u

United statesSareh parangiMichelle garlinMiles millerNabeel bardeesyMark prytyskachChris rodellHannes mikulaRalph weisslederRainer kohlerThyroid cancer survivor associationNational cancer instituteDepartment of radiologyNational institutes of healthDrug administrationNational science foundation