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The door has finally opened on screening newborn babies for pyridoxine-dependent epilepsy (PDE), a severe inherited metabolic disorder. This screening promises to enable better and earlier treatment of the disease. To identify new biomarkers that can be used in the newborn screening protocol, also known as the neonatal heel prick, researchers at the Radboud University Medical Center joined forces with scientists at the Radboud University s FELIX laser laboratory. They published their findings in The
Journal of Clinical Investigation.
The discovery and identification of the new biomarkers could lead to an important addition to worldwide newborn screening protocols. Currently, there are over a thousand known inborn metabolic diseases (IMD), but only 2% of them can be detected through the neonatal heel prick. While these are relatively rare as individual disorders, in the Netherlands, every other day a child is born with an IMD. These disorders have severe health consequenc
Grown bone
Put away your Skele-gro, because growing new bones might be the realm of science, not magic.
Researchers at Eindhoven University of Technology and Radboud University Medical Center, in The Netherlands, have grown the most life-like piece of bone tissue to date, using human stem cells.
“With this, we present, for the first time, the full picture of early-stage bone formation,” says Sandra Hofmann of Eindhoven University of Technology.
Key research points
Bone cells were grown from human stem cells.
Organoid contained multiple cell types.
This could be used to learns the molecular process of bone growth.
Bones are very complex materials that require both a precise matrix of collagen and mineral and intricate cells and cellular processes. Together, this means that growing actual bones is a multi-faceted process.
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