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NOT REAL NEWS: A look at what didn t happen this week
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Frequent testing improves the detection of SARS-CoV-2
Detecting SARS-CoV-2, the virus that causes COVID-19, improves with regularity of testing, whether using rapid antigen tests or PCR molecular tests. The PCR test is considered the gold standard for diagnosing COVID-19 infection, but cost and infrastructure issues, as well as wait times for PCR results, have limited its use more broadly as a screening tool for asymptomatic people because rapid results are needed to interrupt the chain of transmission.
In a highly anticipated study that compares rapid antigen and laboratory PCR approaches for COVID-19 serial screening, researchers affiliated with the National Institutes of Health s Rapid Acceleration of Diagnostics (RADx) initiative reported results from 43 people infected with the virus. They found that both testing methods were equally effective in detecting SARS-CoV-2 infection when tests were given on a regular cadence every three days.
NIH-funded screening study builds case for frequent COVID-19 antigen testing
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Lab reports 1st instance of SARS-CoV-2 variants affecting antigen test performance
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has entered the second year and is marked by the emergence of several new and more infectious variant lineages. Many of these variants are also associated with immune escape.
The mutations in these variants are usually in the spike protein, which evolves rapidly in coronaviruses because of the continual need to escape humoral immunity. The evolution of the virus has affected many aspects of the COVID-19 pandemic, including mortality, therapeutic and vaccine efficacy, and diagnostic assay performance. While the viral evolution has impacted several FDA-authorized diagnostic tests, it has not affected the performance of antigen tests so far.