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1Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, Hunan Province, 410008, People’s Republic of China;
2Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, 410008, Hunan, People’s Republic of China;
3Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, Hunan Province, 410008, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Xu
Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, Hunan Province, 410008, People’s Republic of China
Objective: To detect the expression level of tRNA-derived fragments secreted by extracellular vesicles in hypopharyngeal cancer and explore the influence of tRNA-derived fragments on the occurrence of hypopharyngeal cancer and lung metastasis.
14 have been identified to promote cervical cancer progression, suggesting the important role of circRNAs in cervical cancer tumorigenesis. As for circ 0003221 (also known as circPTK2, chr8:141856358–141900868), it has been demonstrated to be overexpressed in cervical cancer cells.
15 Nevertheless, the role of circ 0003221 in cervical cancer remains largely unclear.
Large evidence has shown that circRNAs can serve as competing endogenous RNAs (ceRNAs), also known as microRNA (miRNA) sponges, via competitively binding to miRNA response elements, thereby regulating the expression of downstream target genes.
16,17 Based on this regulation, circRNAs can function as miRNA sponges to regulate the expression of target genes, forming a regulatory circRNA-miRNA-mRNA network. MiR-758 has been identified to serve as a tumor-suppressing miRNA in cervical cancer.