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Gene-editing technique could speed up study of cancer mutations

In an advance that could help scientists learn more about cancer-linked mutations whose roles are not known, MIT researchers have developed a way to easily engineer specific cancer-linked mutations into mouse models, using CRISPR prime editing.

Peyton randolphQiaobing xuBrendan hortonGrissel cervantes jaramilloNicolas mathey andrewsSean luc shanahanAndrew anzaloneZachary kulstadDavid liuKim mercerGregory newbyKatie hollandJennifer khirallahTyler jacksStefani sprangerSamuel gould

New cancer vaccines eliminate tumors and prevent cancer recurrence

New cancer vaccines eliminate tumors and prevent cancer recurrence
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Qiaobing xuProceedings of the national academy sciencesTufts universityNational academy

Next generation mRNA vaccines exhibit excellent protective and therapeutic effects

Researchers around the world have been working for years on developing vaccines against different types of cancer, but without much success. Now, Tufts School of Engineering researchers think they have found one that does work. They have devised a method of targeting cancer in mice with a vaccine that is so strong and precise, it eliminates tumors and even prevents their recurrence.

Jinjin chenQiaobing xuEmily hendersonTufts school of engineeringProceedings of the national academy sciencesTufts universityTufts schoolBiomedical engineeringNational academyImmune responseImmune systemLymph nodesLymphatic systemNext generation

Targeted cancer vaccines eliminate tumors – Innovations Report

Targeted cancer vaccines eliminate tumors – Innovations Report
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Jinjin chenQiaobing xuTufts school of engineeringProceedings of the national academy sciencesMethod of researchTufts universityTufts schoolNational academyPublication dateHopewell therapeutics

Targeted cancer vaccines eliminate tumors and prevent recurrence

Targeted cancer vaccines eliminate tumors and prevent recurrence
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Jinjin chenQiaobing xuChangfeng huangYamin liTufts school of engineeringProceedings of the national academy sciencesTufts universityTufts schoolNational academyMin qiuDonghui song