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Updated News -Researchers Unveil Extensive Brain Gene Regulation Maps

Updated News -Researchers Unveil Extensive Brain Gene Regulation Maps
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Joshuaa gordonNational institutes of healthPsychencode consortiumNational institute of mental healthNational institutesMental healthScientific reportsScience advances

Dissecting post-traumatic stress disorder and depression

Scientists from the PsychENCODE Consortium have analyzed the brain transcriptome in a coordinated series of studies to map all the cell types, genes, epigenetic factors, and molecular pathways involved in different psychiatric disorders. After a first set of projects based on bulk analysis, the second phase of this project included 14 simultaneous publications that revealed the cellular atlas of post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), among others.

Psychencode consortium

Brain cell maps, the neurological zoom of psychiatric disorders

Understanding psychiatric disorders at a cellular and molecular level could provide a different perspective to design diagnostic and therapeutic tools searching for the origin of these disorders and the alterations they cause. Fourteen simultaneous studies from the PsychENCODE Consortium have delved into the cellular atlases of human neurodevelopment, reporting the broadest view of neuropsychiatry to date.

Psychencode consortium

Two new studies offer insights into the molecular biology of neuropsychiatric disease

Working under the umbrella of the PsychENCODE Consortium, the mental health research project established in 2015 by the National Institutes of Health, a team of Mount Sinai scientists has uncovered important new insights into the molecular biology of neuropsychiatric disease through two new studies published in a special issue of Science on Friday, May 24.

Biao zengPanos roussosJohn fullardNash family department of neuroscienceMindich child healthDepartment of geneticsNational institutes of healthGenomic sciencesPsychencode consortiumMount sinai health systemIcahn institute for data scienceGenomic technologyDevelopment instituteSeaver autism centerDepartment of psychiatryIcahn school of medicine at mount sinai

Scientists map networks regulating gene function in the human brain

A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. These maps detail the many regulatory elements that coordinate the brain s biological pathways and cellular functions. The research used postmortem brain tissue from over 2,500 donors to map gene regulation networks across different stages of brain development and multiple brain-related disorders.

Jonathan pevsnerJoshuaa gordonPsychencode consortiumGenomics research branchNational institute of mental healthMental healthScience advances