Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperone
A team of researchers has found a link between strains of misshapen and fast-replicating tau protein and accelerated cognitive decline a critical result that
A team of researchers has found a link between strains of misshapen and fast-replicating tau protein and accelerated cognitive decline a critical result that could help lead to more precise diagnoses and targeted therapies.
A team of researchers has found a link between strains of misshapen and fast-replicating tau protein and accelerated cognitive decline a critical result that
An international team lead by Case Western Reserve University’s School of Medicine has made a significant breakthrough in understanding why Alzheimer’s