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 E-Mail Apathy - a lack of interest or motivation - could predict the onset of some forms of dementia many years before symptoms start, offering a window of opportunity to treat the disease at an early stage, according to new research from a team of scientists led by Professor James Rowe at the University of Cambridge. Frontotemporal dementia is a significant cause of dementia among younger people. It is often diagnosed between the ages of 45 and 65. It changes behaviour, language and personality, leading to impulsivity, socially inappropriate behaviour, and repetitive or compulsive behaviours. A common feature of frontotemporal dementia is apathy, with a loss of motivation, initiative and interest in things. It is not depression, or laziness, but it can be mistaken for them. Brain scanning studies have shown that in people with frontotemporal dementia it is caused by shrinkage in special parts at the front of the brain - and the more severe the shrinkage, the worse the apathy.

United kingdomMaura malpettiRogier kievitJames roweBrain sciences unit at cambridgeJournal of the alzheimer associationRadboud university medical center at nijmegenDepartment of clinical neurosciencesUniversity of cambridgeNational institute for health researchResearch councilDonders instituteProfessor james roweClinical neurosciencesGenetic frontotemporalProfessor rowe