Approximately one third of children born to mothers infected with Zika virus during their pregnancy present with at least one abnormality consistent with Congenital Zika Syndrome in the first years of their life, according to new research. The findings based on the pooled analysis of 13 studies investigating paediatric outcomes among over 1,500 pregnancies affected by Zika virus during the 2015–2017 epidemic in Brazil improve our understanding of the risks associated with prenatal Zika virus infections, with important public health implications.