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World s first fully reversible manipulation of the circadian clock The Nagoya University Institute of Transformative Bio-Molecules (WPI-ITbM) research team of Designated Associate Professor Tsuyoshi Hirota, Postdoctoral Fellow Simon Miller, Professor Kenichiro Itami and graduate student Tsuyoshi Oshima (Research Fellowship for Young Scientists, JSPS), in collaboration with the group of Professor Ben Feringa and Postdoctoral Fellow Dušan Kolarski of Groningen University in the Netherlands, have achieved a world first: fully reversible manipulation of the period of the circadian clock using light, by exchanging part of a compound with a light-activated switch. Waking in the morning, sleeping at night - the majority of our biological activities repeat within a daily cycle. The internal process which governs this rhythm is known as the circadian clock. While it is understood that the circadian clock is controlled by the combined functions of clock genes and clock proteins, the process

Tsuyoshi hirotaKenichiro itamiSimon millerBen feringaEmily hendersonTsuyoshi oshima research fellowship for young scientistsNagoya university institute of transformative bioGroningen universityNagoya university instituteTransformative bio moleculesDesignated associate professor tsuyoshi hirotaPostdoctoral fellow simon millerProfessor kenichiro itamiTsuyoshi oshimaResearch fellowshipYoung scientists