Organoid bladders reveal secrets of UTIs miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
UTI Dynamics Captured by Bladder Organoids and Bladder Chips
Electron microscopy reconstruction of the various bacterial niches. [Sharma et al., EPFL]
July 30, 2021
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As stubborn as they are common, urinary tract infections (UTIs) have attracted intense scrutiny, but much about them remains hidden. Scientists know that they begin with intracellular bacterial communities (IBCs), and that these communities, which grow inside the cells lining the bladder’s wall, burst free, unleashing an infectious cascade that eventually reaches the bladder’s deeper layers, where quiescent intracellular reservoirs (QIRs) form. However, scientists haven’t been able to observe these events in detail. Consequently, scientists have little idea of how to prevent or eliminate QIRs, which are notorious for promoting antibiotic resistance and causing recurrent infections.
Researchers develop two complementary bladder models to study UTIs news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.