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Addex Therapeutics Ltd: Addex, Stanford University and University of Copenhagen Publish mGlu2 Structure in Nature Using Addex Allosteric Modulators Data could enable acceleration of lead optimization using computer aided drug discovery tools Addex existing mGlu2 positive allosteric modulator, ADX71149, in clinical studies for epilepsy and mGlu2 negative allosteric modulators in preclinical development for neurocognitive disorders Ge 2 1 - Addex Therapeutics (SIX: ADXN and Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug discovery and development, today announced research revealing structures of the metabotropic glutamate receptor 2 (mGlu2) in complex with one of Addex s mGlu2 positive allosteric modulators (PAMs). The study, published in Nature, was headed by Professor Georgios Skiniotis (Stanford University) in collaboration with the University of Copenhagen and Addex.

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