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The Mark Foundation for Cancer Research announces a $1 million grant to The Jackson Laboratory (JAX) to study the harmful side effects that sometimes occur in cancer patients treated with immunotherapy. The research will involve mice engineered with humanized immune systems to find specific gene variants that could explain why so many patients - as many as 10 percent - develop Type 1 diabetes while undergoing immunotherapy to treat cancer. The grant will also study and determine how to predict which patients may experience myocarditis, a rare but potentially deadly inflammation of the heart that immunotherapy can also trigger.
This new grant project, Identifying Genes Uniquely Contributing to ICI-induced Immune Related Adverse Events, led by Professor Dave Serreze, Ph.D., and Scientific Director and Professor Nadia Rosenthal, Ph.D., F.Med.Sci., builds upon a $2.5 million grant the Mark Foundation awarded to JAX in 2019 aimed at determining how genetics influence immunother