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Weizmann Institute Optogeneticists Use Mosquito Rhodopsins to Boost Brain Research
New versions of light-sensitive proteins could illuminate the dark corners of our brain’s communication pathways
Weizmann Institute of Science
Segment of a mouse brain. Red illuminated areas are communication pathways between neurons that express the mosquito-derived protein. In blue: cells’ nuclei
Weizmann Institute of Science
Illustration of the mosquito rhodopsin’s structure. Efficient and stable Previous Next
Newswise Can a protein found in a mosquito lead to a better understanding of the workings of our own brains? Prof. Ofer Yizhar and his team in the Weizmann Institute of Science’s Department of Neurobiology took a light-sensitive protein derived from mosquitos and used it to devise an improved method for investigating the messages that are passed from neuron to neuron in the brains of mice. This method, reported in
Hamburg
Germany
Berlin
Simon-wiegert
Ofer-yizhar
Inbar-saraf-sinik
Shaked-palgi
Pritish-patil
Jonas-wietek
Hanna-litvin
Ido-davidi
Eyal-bitton
Weizmann Institute of Science
Can a protein found in a mosquito lead to a better understanding of the workings of our own brains? Prof. Ofer Yizhar and his team in the Weizmann Institute of Science’s Neurobiology Department took a light-sensitive protein derived from mosquitos and used it to devise an improved method for investigating the messages that are passed from neuron to neuron in the brains of mice. This method, reported today in Neuron, could potentially help scientists solve age-old cerebral mysteries that could pave the way for new and improved therapies to treat neurological and psychiatric conditions.
Yizhar and his lab team develop so-called optogenetic methods – research techniques that allow them to “reverse engineer” the activity of specific brain circuits in order to better understand their function. Optogenetics uses proteins known as rhodopsins to control the activity of neurons in the mouse brain. Rhodopsins are light-sensing proteins – they are most
Hamburg
Germany
Berlin
Ofer-yizhar
Simon-wiegert
Inbar-saraf-sinik
Shaked-palgi
Pritish-patil
Jonas-wietek
Hanna-litvin
Ido-davidi
Eyal-bitton
Can a protein found in a mosquito lead to a better understanding of the workings of our own brains? Prof. Ofer Yizhar and his team in the Weizmann Institute of Science’s Neurobiology Department took a light-sensitive protein derived from mosquitos and used it to devise an improved method for investigating the messages that are passed from neuron to neuron in the brains of mice. This method, reported today in
Neuron, could potentially help scientists solve age-old cerebral mysteries that could pave the way for new and improved therapies to treat neurological and psychiatric conditions.
Yizhar and his lab team develop so-called optogenetic methods – research techniques that allow them to “reverse engineer” the activity of specific brain circuits in order to better understand their function. Optogenetics uses proteins known as rhodopsins to control the activity of neurons in the mouse brain. Rhodopsins are light-sensing proteins – they are most known for their role in organ
Hamburg
Germany
Asaf
Hadarom
Israel
Berlin
Simon-wiegert
Ofer-yizhar
Inbar-saraf-sinik
Shaked-palgi
Pritish-patil
Jonas-wietek
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