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India faces critical challenge as WHO lists rifampicin-resistant TB as major threat

WHO Updates List of Antibiotic-Resistant Bacteria, After Seven Years

The World Health Organization has updated the list of antibiotic-resistant bacteria after seven years and categorized them into groups based on criticality.

Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal

Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by the classic membrane permeabilization model1. Recently, the clinically vital but also highly renal-toxic small-molecule natural product amphotericin B was instead found to kill fungi primarily by forming extramembraneous sponge-like aggregates that extract ergosterol from lipid bilayers2–6. Here we show that rapid and selective extraction of fungal ergosterol can yield potent and renal-sparing polyene antifungals. Cholesterol extraction was found to drive the toxicity of amphotericin B to human renal cells. Our examination of high-resolution structures of amphotericin B sponges in sterol-free and sterol-bound states guided us to a promising structural derivative that does not bind cholesterol and is thus renal sparing. This derivative was also less potent because it extracts ergosterol more slowly. Selective acceleration of ergosterol extraction with a second structural modification y

Coordination, collaboration key to solving crisis of antibiotic development

The impact of inpatient bloodstream infections caused by antibiotic-resistant bacteria in low- and middle-income countries: A systematic review and meta-analysis

Kasim Allel and colleagues systematically review published literature from low- and middle-income countries and meta-analyse data extracted from 109 articles to explore the impact of bloodstream infections caused by antibiotic-resistant bacteria.