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The hepatitis E virus protein ORF1 contains a region that scientists have struggled to characterize, making the structure and function of this region the subject of much debate. Now, Princeton scientists show that this region of the protein does not behave as a protease, as has been previously suggested, but instead serves as a molecular scaffold to stabilize the rest of the ORF1 protein.
A Princeton-led team of researchers from the University, MIT, Harvard, and Editas Medicine developed and applied a new method to understand the activity of cellular genes involved in correcting DNA damage, paving the way for dramatic improvements to genome-editing technologies. These advances are described in a pair of papers that appeared online Oct. 14 and Oct. 20, 2021, in the journal "Cell."