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Introduction Social determinants of health, such as living and working conditions, economical and environmental context and access to care, combine to impact the health of individuals and communities. In French Guiana (FG), the persons working in informal artisanal and small-scale gold mining in the rainforest are a particularly vulnerable population which lives in precarious conditions and far from the health system. Previous studies have demonstrated their high morbidity due to infectious diseases. This study aims to describe the social determinants of health in this specific population. Methods This international multicentre cross-sectional survey included people working on the informal FG gold mines at the crossing points located at both borders with Suriname and Brazil. After collecting written informed consent, a structured questionnaire was administered. Results From September to December 2022, 539 gold miners were included. These poorly educated migrants, mainly from Brazil (

French guianaUnited statesEteläuomen läiMaroni riverSuriname generalFrench guiana generalMensgebonden wetenschappelijk onderzoekPaul le turnierRonnie edisonPierre massatEstelle thomasGeneva charterLucia verdejoPolice operationHealth centerCentre de ressources biologiques amazonie