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Leaning on family support to navigate diagnosis challenges

CURE provides access to the cancer news, latest oncology research & expert insights that serve as a guide to every stage of the cancer experience.

United statesOptune gioMike hugoNational cancer instituteAmerican association of neurological surgeonsTumor treating fieldsFlorida keysOptune gio instructionsPrimary brainAccessed septemberClinj oncolBrain tumor surgeryMaintenance temozolomide alonePatients with

Ascletis Announces Completion of Enrollment of 120 Patients in the Phase III Clinical Trial of FASN Inhibitor ASC40 Combined with Bevacizumab for Treatment of Recurrent Glioblastoma

/PRNewswire/ Ascletis Pharma Inc. (HKEX: 1672, "Ascletis") today announces the completion of enrollment of 120 patients in the Phase III registration.

Hong kongUnited statesActa neuropatholJinzij wuHong kong stock exchangePrnewswire ascletis pharma incWorld health organizationAscletis pharma incAcid synthaseHealth organizationCancer registry annualPrimary brainAscletis pharma inc

Brain and Spinal Cord Cancers

The neuro-oncology team at Fred Hutchinson Cancer Center and UW Medicine has a wide breadth of expertise in both primary brain cancers and in brain and spinal cord metastases.

Fred hutchGamma center at harborview medicalBrain spinal cord cancer care teamAlvord brain tumor centerFred hutchinson cancer centerUw medical centerFred hutch brainSpine metastases clinicGamma centerHarborview medical centerPrimary brainSpinal cordSpinal cord cancersBrain and spinal cord cancers

ONO PHARMA USA s Tirabrutinib Receives Orphan Drug Designation from the FDA for the Treatment of Primary Central Nervous System Lymphoma

ONO PHARMA USA s Tirabrutinib Receives Orphan Drug Designation from the FDA for the Treatment of Primary Central Nervous System Lymphoma
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United statesUnited kingdomSouth koreaKunihiko itoDrug administrationOno pharmaceutical co ltdOrphan drug designationDrug designationPrimary brain

Frontiers | GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma

Background Glioma is a lethal primary tumor of central nervous system. Ferroptosis is a newly identified form of necrotic cell death. Triggering ferroptosis has shown potential to eliminate aggressive tumors. GPX7, a member of glutathione peroxidase family (GPXs), has been described to participate in oxidative stress and tumorigenesis. However, the biological functions of GPX7 in glioma are still unknown. Methods Bioinformatics method was used to assess the prognostic role of GPX7 in glioma. CCK8, wound healing, transwell and cell apoptosis assays were performed to explore the functions of GPX7 in glioma cells. In vivo experiment was also conducted to confirm in vitro findings. Ferroptosis-related assays were carried out to investigate the association between GPX7 and ferroptosis in glioma. Results GPX7 was aberrantly expressed in glioma and higher expression of GPX7 was correlated with adverse outcomes. GPX7 silencing enhanced ferroptosis-related oxidative stress in glioma cells and t

United statesUnited kingdomDunfa pengBiochim biophys actaSilva mcdaChin neurosurgDuttaa micrornasLiuy erastinZheng chenExtensive networkHuanhu hospital department of neurosurgeryBeina chuanglian biotechnology instituteDojindo molecular technologySunz global research trends of ferroptosisCell bioscience incCommittee of tianjin huanhu hospital