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Addex GABAB Positive Allosteric Modulator Demonstrates Promise in Alcohol Use Disorder
Addex TherapeuticsFebruary 16, 2021 GMT
Review from Linköping University Published in
Alcohol and Alcoholism Journal
Geneva, Switzerland, February 16, 2021 – Addex Therapeutics (SIX: ADXN and Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug discovery and development, today announced that a review published in
Alcohol and Alcoholism suggests that positive allosteric modulators (PAMs) of the gamma-aminobutyric acid B (GABAB) receptor could offer a new treatment option for patients with severe alcohol use disorder (AUD). Direct, orthosteric, GABAB receptor agonists, such as baclofen, have been shown to attenuate addiction-related behaviors in preclinical studies. However, the therapeutic use of baclofen is very limited due to significant side-effec