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 E-Mail PHILADELPHIA Piperlongumine, a chemical compound found in the Indian Long Pepper plant (Piper longum), is known to kill cancerous cells in many tumor types, including brain tumors. Now an international team including researchers from the Perelman School of Medicine at the University of Pennsylvania has illuminated one way in which the piperlongumine works in animal models and has confirmed its strong activity against glioblastoma, one of the least treatable types of brain cancer. The researchers, whose findings were published this month in ACS Central Science, showed in detail how piperlongumine binds to and hinders the activity of a protein called TRPV2, which is overexpressed in glioblastoma in a way that appears to drive cancer progression. The scientists found that piperlongumine treatment radically shrank glioblastoma tumors and extended life in two mouse models of this cancer, and also selectively destroyed glioblastoma cells taken from human patients.

Pennsylvania hospitalUnited statesNew jerseyUniversity of pennsylvaniaUnited kingdomAgencia estatal investigaciVera moiseenkova bellTiago rodriguesRoyal societyPenn medicine princeton healthUniversity of lisbonLancaster behavioral health hospitalElectron microscopy resource laboratoryPerelman school of medicineUniversity of pennsylvania health systemEuropean molecular biology organization installation grant