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Labs should not let in silico data supplant physical specimens in bioinformatic validation and should understand the limitations of such data.

United statesJustin zookAssociation for molecular pathologyAssociation for pathology informaticsNational institute of standardsTapestry networksCollege of american pathologistsGenomic sciences groupPipeline validation working groupMolecular pathologyNational institutePathology informaticsAmerican pathologists