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Novel treatment based on gene editing safely and effectively removes HIV-like virus from genomes of non-human primates
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Gene Editing Eradicates HIV-Like Virus in Primates Safely, Effectively
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Chances of eliminating HIV infection increased by novel dual gene-editing approach
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EMBARGO UNTIL: May 1, 2023 at 3 PM ET
Gene-editing therapy aimed at two targets – HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that helps the virus get into cells – can effectively eliminate HIV infection, new research from the Lewis Katz School of Medicine at Temple University and the University of Nebraska Medical Center (UNMC) shows. The study, published online in the journal The Proceedings of the National Academy of Sciences (PNAS), is the first to combine a dual gene-editing strategy with antiretroviral drugs to cure animals of HIV-1.