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 E-Mail IMAGE: Nascent cells in red, neurons in green. The cells in pink are new neurons to be integrated into a neural network view more  Credit: © UNIL-CHUV- Carron / Toni Depression is the leading cause of disability worldwide. Neuroscientists from Synapsy - the Swiss National Centre of Competence in Research into Mental Illness - based at Lausanne University Hospital (CHUV) and Lausanne University (UNIL) have recently demonstrated that lactate, a molecule produced by the body during exercise, has an antidepressant effect in mice. Lactate is best known for the pivotal role it plays in the nutrition of neurons inside the brain. Yet it can also counter the inhibition of the survival and proliferation of new neurons, a loss seen in patients suffering from depression and in stressed animal. Furthermore, the research team pinpointed NADH as a vital component in the mechanism: this is a molecule with antioxidant properties that is derived from the metabolism of lactate. T

Anthony carrardJean luc martinPierre magistrettiLausanne universityCentre for psychiatric neurosciencesLausanne university hospitalSwiss national centre of competenceSwiss national centreMental illnessMolecular psychiatryPsychiatric neurosciencesProfessor pierre magistrettiCell biologyMolecular biologyNutrition nutrientsMedicine health