Durham Regional Police said the crash took place near Uxbridge Townline and Sideline 28 after 10 a.m. Police were called to reports of a single-vehicle collision.
A young man heading back home along Highway 401 on Tuesday night said he was one of the last cars to make it out of the area before a fuel tanker truck exploded on the roadway.
Ontario Provincial Police say a multi-vehicle collision has claimed two lives and sparked a massive fireball on Highway 401, at Brock Road in Pickering, east of Toronto.