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Researchers show zinc plays a key role in inflammatory bowel disease and leaky gut

Researchers show zinc plays a key role in inflammatory bowel disease and leaky gut
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Christer hogstrandNature communicationsPeriodic acid schiffAryl hydrocarbon receptor

Nanocomposite Formulation for Therapy of Ocular Diseases

To improve the anti-angiogenic or anti-inflammatory effects, a dual-drug nanocomposite formulation was proposed for the therapy for ocular vascular diseases.

United statesUnited kingdomMicrometrics tristarCell systems corporation united kingdomQinglongshan experimental animal centerVision researchZetasizer malvern instrumentRelease studyCell systems corporationAmerican tissue culture collectionMolecular devicesInduced inflammatory responseAnimal careUse committeePeriodic acid schiffWhitneyu test

Suyin detoxification granule inhibits pyroptosis

Chinese herbal medicine suyin detoxification granule inhibits pyroptosis and epithelial-mesenchymal transition by downregulating mavs/nlrp3

United statesUnited kingdomHuang qiFu lingAda huangZhong huaYin chenYuanye bioServicebio hubeiLiu yue xueTu fu linAbcam cambridgeShan zhu yuPu huangUniversity of chinese medicineLaboratory animals

Maternal high-fat diet programs

Maternal obesity impairs kidney development and function of the offspring and leads to a greater risk of kidney disease in adulthood.

United statesPeroxins pexsNational institutes of healthTakara biotechnology co ltdNikon corporationMillipore corporationAbbott laboratoriesKidney histopathology development indicesAnimal research committeeShengjing hospitalChina medical universityNational institutesAbbott parkPeriodic acid schiffBiological industriesLipid peroxidation

Topical delivery of Levocarnitine for Dry Eye Disease

Discussion New technologies have been explored in many researches such as a kind of long-acting mucoadhesive thermogels and gallate-loaded gelatin-g-poly (N-Isopropylacrylamide) for the treatment of DED. As the first recommended drug in “Dry Eye Diagnosis and Treatment Guidelines”, the protective effect of LC on corneal epithelial cells under hypertonic state has been verified. 22–24 Another research group prepared an artificial formulation which also used LC as a part of formulation to help replenish the tear film. 25 In this study, a kind of thermosensitive in situ gel of LC was prepared which is in a floating condition at room temperature while can form a gel rapidly as soon as dropped in the ocular surface of rabbits. The mechanism of the gelatinization under specific temperature of LCTG was relevant with hydrophobic effect of groups, hydrogen-bond interaction among polymer chains and hydrogen-bond interaction among hydrophilic group. On the one hand, LCTG can give full

United statesRheinland pfalzNew zealandGroup liaoningDanjier ltdTechnology shanghaiOcular surface associationDry eye diseasesDry eye working groupInternational tear filmEye diagnosisNortheast pharmaceutical groupPush bio technologyShenguang edilble chemicalsPeriodic acid schiffGoat anti rabbit igg